An Inflammatory Cytokine Milieu is Prominent in Premalignant Oral Lesions, but Subsides when Lesions Progress to Squamous Cell Carcinoma

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An Inflammatory Cytokine Milieu is Prominent in Premalignant Oral Lesions, but Subsides when Lesions Progress to Squamous Cell Carcinoma

While head and neck squamous cell carcinomas (HNSCC) are associated with profound immune suppression, less is known about the immunological milieu of premalignant oral lesions. The present study shows dynamic shifts in the immune milieu within premalignant oral lesions and when they have progressed to HNSCC. Specifically, this study showed that the premalignant lesion environment consists of in...

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An unusual oral squamous cell carcinoma of the mandible, mimicked inflammatory hyperplastic lesions: A case report

        Abstract   Squamous cell carcinoma (SCC) is the most common malignant tumors of oral cavity. The ratio of men to women is about 2: 1. Generally, it   is admitted that 60% of carcinoma of the mandibular gingival are located in the posterior of premolars. Gingiva is one of the less common sites of oral squamous cell carcinoma (OSCC). Due to the variable clinical and behavioral presentatio...

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an unusual oral squamous cell carcinoma of the mandible, mimicked inflammatory hyperplastic lesions: a case report

abstract   squamous cell carcinoma (scc) is the most common malignant tumors of oral cavity. the ratio of men to women is about 2: 1. generally, it   is admitted that 60% of carcinoma of the mandibular gingival are located in the posterior of premolars. gingiva is one of the less common sites of oral squamous cell carcinoma (oscc). due to the variable clinical and behavioral presentations, it c...

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Apoptotic Index and Proliferative Index in Premalignant and Malignant Squamous Cell Lesions of the Oral Cavity

BACKGROUND Oral squamous cell lesions are most commonly diagnosed lesions in India. Both premalignant and malignant lesions are frequently encountered. In this study, we evaluated the role and significance of apoptotic indices (AI) and proliferative indices (PI) in premalignant and malignant squamous cell lesions of the oral cavity. MATERIALS AND METHODS A total of 62 histologically proven ca...

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Mast Cell Count Analysis in Oral Inflammatory Lesions, Potentially Malignant Disorders and Oral Squamous Cell Carcinomas

Background: Mast cells have been studied for decades due to their prominent role in normal homeostasis and various pathologies. They display a diversity of roles and are proposed to be a part in the pathogenesis of various pathologic lesions. Aims and Objectives: To histologically evaluate the number of mast cells in tissue sections of oral inflammatory lesions, potentially malignant disorders ...

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ژورنال

عنوان ژورنال: Journal of Clinical & Cellular Immunology

سال: 2014

ISSN: 2155-9899

DOI: 10.4172/2155-9899.1000230